Do Natures make a big difference Pokémon?

Do Natures make a big difference Pokémon? Natures will increase the affected stat by 10% during growth, and decrease the other affected stat by 10% during growth. It makes definitely a notable difference, if not a huge one. Just imagine a Pokemon with an Sp. Atk base stat of 150, such as Dialga.

Natures will increase the affected stat by 10% during growth, and decrease the other affected stat by 10% during growth. It makes definitely a notable difference, if not a huge one. Just imagine a Pokemon with an Sp. Atk base stat of 150, such as Dialga.