What is the most famous villain in gaming history? What is the most famous villain in gaming history? 10 Most Iconic Video Game Villains, Ranked 7 GLaDOS Takes The Cake. 6 The Joker From The Arkham Series Is Unique. 5 Andrew Ryan Is As Enigmatic As They Come. 4 Sephiroth Is A Villain With Multiple Dimensions. 3 Ganondorf Is...