Who holds the record for most strikeouts in a game?

Who holds the record for most strikeouts in a game? Notes. The overall record for most strikeouts in a game is 21, by Tom Cheney of the Washington Senators against the Baltimore Orioles, over 16 innings on Sept. 12, 1962 (Washington won 2-1).

Notes. The overall record for most strikeouts in a game is 21, by Tom Cheney of the Washington Senators against the Baltimore Orioles, over 16 innings on Sept. 12, 1962 (Washington won 2-1).